Even though there was an increased risk, the percentages were still fairly low
For many people, these symptoms subside within a few days of an injection or disappear entirely after the body adjusts to the medication over several months
Read more about managing constipation while on GLP-1 meds here
3335 Autoimmunity against DPP4 has also been observed in RA patients, suggesting a potential role for DPP4 in the autoimmune response associated with the disease
"The trials showed that for weight loss to be really effective, semaglutide should be prescribed to people who also access intensive behavioural change therapy to support them adopting healthier lifestyles." Prof Holt explains that the medication is ultimately a stop-gap approach to help people lose weight in the short-term, rather than a permanent option
After 10 years of treatment, the incidence of MALE was significantly lower in the GLP-1RAs group than in the non-GLP-1RAs group (Celsa et al., 2025)