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Transcriptomic analysis has shown modulation of over 500 genes, while calcium channel antagonists, such as verapamil and amlodipine, increase PMM susceptibility, implicating ABC transporters in the resistance pathway

Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPAR

Expanding the spectrum of BAF-related disorders: de novo variants in SMARCC2 cause a syndrome with intellectual disability and developmental delay

Oxidized PAC-quinone imine metabolites have also been shown to form GSH-conjugates which inhibit glutathione reductase (GR): the decreased activity of GR hampers the detoxification and antioxidant capacity of the GSH-GSSG cycle, further aggravating the pro-oxidative status in the cell (Ndlov et al., 2014)

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