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Our study suggests that the increased expression and nuclear distribution of p53-pS15 in keloids are associated with the promotion of pro-senescence regulation causing the cell cycle arrest and resistance to apoptosis

The N-terminal hexanoyl cap and specific hydrophobic amino acid sequence (Tyr-Ile-Ahx) were engineered specifically to increase lipophilicity and metabolic stability, allowing Dihexa to cross cell membranes and the blood-brain barrier intact in preclinical models

Technically yes, but the risk profile changes significantly

But only one is designed for repeated access from the same vial