semaglutide reddit before and after I reached my goal Before and after 1.5yrs apart

doi: 10.1210/en.2011-1864 67 van den BrinkWEmerencianaABellantiFDella PasquaOvan der LaanJW

Dec 2011;24(4):163-180

8 Challenges and Considerations in Multi-Agonist Therapy Despite their advantages, GLP-1-based therapies face several challenges in adolescent populations: Gastrointestinal Side Effects: Nausea, vomiting, diarrhea, and constipation are common adverse events, especially during dose escalation

Some studies suggest that it could be responsible for causing an L-Carnitine deficiency as it promotes the absorption of other forms

Other mechanisms such as VPA-induced lipid peroxidation and glutathione depletion could also contribute to hepatotoxicity [59]

Side effects like mild nausea or digestive changes are common in the first 12 weeks but usually resolve as your body adjusts