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GLP-1 medications can be powerful tools for weight reduction and metabolic improvements, especially for individuals with significant obesity or diabetes-related complications

3.3 Drug delivery systems Whilst not specifically a tissue engineered approach, drugs are often incorporated into such constructs and used in the remodelling of the TME (Ye et al., 2019)

Competitive Displacement: FOXO4-DRI mimics the binding site of FOXO4. It binds to p53 with high affinity, displacing the endogenous FOXO4

Methods Healthy lean (L-ZSF1, n = 12) and obese ZSF1 rats with HFpEF (O-ZSF1, n = 12) were studied

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