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Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor

HO-1 promotes the synthesis of powerful endogenous antioxidants biliverdin and bilirubin

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Studies have demonstrated that agonists of these receptors reduce serum bilirubin and increase urinary excretion of glucuronidated products in cholestatic models [55,56,57]