Composite endpoints that include metabolic endpoints, validated psychological measures such as the PHQ-9 for depression, BES or measures of quality of life can better reflect improvements in both physical and mental health [41]
Looking to build a winning obesity strategy
Fiber-rich and nutrient-dense Whole foods like vegetables, legumes, and healthy fats help keep digestion smooth and support gut health both important on a GLP-1 journey
If a patient already has slow stomach emptying, known as gastroparesis, a GLP or GLP/GIP should likely be avoided, as this condition will only worsen when the medication is started, often leading to intolerable side effects
Maci-Dankovi A
Indeed, in the cardiovascular outcome trial (CVOT) for semaglutide, SUSTAIN 6 a relatively short (two-year) and small (3,297 individuals) preregistration trial (an extensive CVOT in obese individuals without T2DM (SELECT) is expected to complete in 2024) HbA 1c was powerfully and durably reduced