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A 2025 systematic review in Orthopaedic Sports Medicine analyzed 36 studies on BPC-157 and found that the peptide improved functional, structural, and biomechanical outcomes in muscle, tendon, ligament, and bone injury models

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Diarrhoea (defined as three or more loose or watery stools per day) is an uncommon side effect of vitamin B12 supplementation , though it is listed as a rare or uncommon adverse reaction in the official product information for both oral cyanocobalamin and injectable hydroxocobalamin preparations