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Severe cases may require surgery
One of the major trials of tirzepatide (the active ingredient in Zepbound and Mounjaro ) showed participants losing an average of 15%--21% of their body weight over a period of 72 weeks, with more weight loss in those taking the highest dose of the drug
Stratified by GLP-1 related and non GLP-1 related treatments In the included RCTs, GLP-1 related drugs (including liraglutide, semaglutide, beinaglutide, exenatide, and AMG133) showed significant weight regain compared with control group (WMD = 1.78 kg, 95% CI 0.76 to 2.80, P = 0.006, I 2 = 85%)
What Clinical Trials Reveal About Tirzepatide and Emotional Side Effects The SURMOUNT clinical trial program, which evaluated tirzepatide in over 18,000 patients, documented mood-related adverse events at rates comparable to placebo in most cohorts
Hes bet the farm on the pills, and theyre going to fail