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The same study also suggested a lower risk of dementia compared to sitagliptin

Remarkably, participants in the SELECT trial experienced a significant 20% reduction in major adverse cardiovascular events , underscoring semaglutides role in cardiovascular disease prevention

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Reactive oxygen species also contribute to the activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, which facilitates the maturation and secretion of interleukin-1 (IL-1) and IL-18, further amplifying inflammation (Dominic et al., 2022)