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The pharmacodynamic effects of chronic sitagliptin therapy, administered alone or in combination with metformin, were assessed in 16 subjects with type 2 diabetes treated with metformin or sitagliptin, alone or in combination, for 6 weeks (173)

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Unlike cisplatin and similarly to other antiarthritic gold drugs, auranofin appears to exert its activity through inhibition of enzyme activities rather than DNA damage

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In these cases, oral supplements may not be effectively absorbed, making B12 injections a more reliable treatment option