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Meanwhile, mTORC1/S6K1 can also phosphorylate IRS-1 serine, thus block its activation 80 (Fig

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According to the most recent WHO report, 2023 Antibacterial agents in clinical and preclinical development: an overview and analysis (data collected up to the end of 2023), there are nearly a hundred new chemical entities in the trials, out of which 26 are labeled as innovative depending on if they meet one or more of the four WHO criteria (new chemical class, new target, new mode of action or absence of cross-resistance) [59]