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Moreover, we discovered that USP2 OE, but not its K447R mutant, led to a decrease in GPX4 mRNA level and a reduction in both GSH and SOD levels, while simultaneously causing an upregulation in ACSL4 mRNA levels and an increase in MDA content under TGF-1 stimulation (Fig

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Lipid peroxidation in aging brain and Alzheimers disease

& Yamanaka, S