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These excess FFAs are delivered to the liver, where they contribute to hepatic triglyceride accumulation, a hallmark of steatosis, and create a pro-inflammatory environment that promotes progression toward fibrosis 9

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For the boost immunization, the mice were injected with the emulsion of bovine type-II collagen solution (2 mg/mL) with incomplete Freunds adjuvant (IFA) on day 21

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