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For prescription availability in Canada right now: Tirzepatide is the closest alternative with strong efficacy (20.9%) and an existing prescription pathway

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This work was supported by the Grant Agency of the Czech Republic (Project 20-09103S

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A conjugation of AITC to glutathione in planta might be non-enzymatic or catalysed by GSTs, as indicated by the AITC-induced upregulation of several GST-encoding genes 17,40,41 and similar to what was recently shown for indol-3-ylmethyl-ITC 35