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Both diatrizoate (methylglucamine salt) and Percoll have been used for the purification [2] but yields are poor and contamination by host cell components remains a problem [2]

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doi: 10.1177/09603271211021476 84 JoshuaDBKyung-DonKNeilVKHannahEOSamGStacieKTet al

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In the case of organic compounds, biotransformation steps are often necessary and their nature, mechanism(s), responsible enzymes and related polymorphisms are well characterized and the respective role in determining individual sensitivity to the effects of exposure at different levels is a well-established field of investigation

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This is in agreement with our previous study in which tamoxifen-resistant cells were reported to have high GLUL levels [22], which was attributed to the activation of the PI3K/AKT/PTEN signaling pathway, which is known to increase proliferation and cellular invasion [33]

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