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While systematic reviews have sought to integrate existing data generating larger cohorts, this inherent heterogeneity and the inability to explore confounders with aggregate data preclude metaanalysis for certain outcomes and raise concerns around the accuracy of pooled estimates for others

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doi: 10.3945/ajcn.116.137158 179 RoivainenAParkkolaRYli-KerttulaTLehikoinenPViljanenTMottonenTet al

The Wegovy package insert says 4% of people taking Wegovy during clinical trials reported anxiety as a side effect

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