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Examples Repaglinide (Prandin) Dosage Initial: 0.52 mg before each meal, up to four times daily Maximum: 16 mg daily, 4 mg per dose Nateglinide (Starlix) Dosage Initial: 60120 mg before meals, up to three times daily Maximum: 360 mg daily, 120 mg per dose Possible side effects include: Hypoglycemia (lower risk than sulfonylureas) Weight gain Bile acid sequestrants Primary mechanism(s) of action Bile acid sequestrants were originally developed and approved to lower LDL-cholesterol

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10.1182/blood.V85.1.257.bloodjournal851257 Blood 31

Patients should be educated about recognising symptoms of hypoglycaemia, particularly if taking Mounjaro alongside other glucose-lowering medications such as insulin or sulphonylureas

Microbial drug resistance (2012))

Adding semaglutide gets you 1.0 to 1.8% on top