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Schlatter P, Beglinger C, Drewe J, Gutmann H

In A Treatise on the Scurvy (1753) [2] [61] [59] Lind explained the details of his clinical trial and concluded "the results of all my experiments was, that oranges and lemons were the most effectual remedies for this distemper at sea." [8] [59] However, the experiment and its results occupied only a few paragraphs in a work that was long and complex and had little impact

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Indeed, intracerebroventricular infusion of PPA in rats decreases total glutathione in brain homogenates

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During radiotherapy, depleting GSH improves treatment efficacy by impairing the cells ability to neutralize ROS [85]