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Authorship All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole and have given their approval for this version to be published

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The sequestration of cystine within lysosomes may deplete cytosolic cysteine, which is essential for glutathione synthesis, leading to impaired redox homeostasis [144, 146]

Mechanistically, HT induced ferroptosis in HCT116 and SW480 cells via the Nrf2 pathway, and our current investigation proposes a possible therapeutic strategy for CRC

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