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The most commonly reported side effects in the Phase 2 trial were gastrointestinal in nature, consistent with the broader GLP-1 receptor agonist drug class

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Satiety & Weight Management Extensive Research Pramlintide promotes satiety and reduces caloric intake through activation of amylin receptors in the area postrema and hypothalamic feeding centers, representing one of its most clinically significant non-glycemic benefits

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At 26 weeks after treatment, the weight loss was -2.29 0.24 kg for 1.5 mg DUL, -1.36 0.24 kg for 0.75 mg DUL, and -2.22 0.24 kg for metformin (110)