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For weight management, successful and durable outcomes depend on sustained lifestyle changes alongside medication use

Glucagon-like peptide-1 (GLP-1) physiologically induces glucose-dependent insulin secretion from -cells and GLP-1 analogues ameliorate hyperglycaemia in T2D patients 4,5,6

Calorie Deficit: With reduced appetite and slower digestion, individuals naturally consume fewer calories, creating the calorie deficit necessary for weight loss

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Berberine: This natural AMPK activator shares mechanism overlap with MOTS-c