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BMJ 306 , 10981101 (1993)

Combining GLP-1 and Metformin for Better Results Building on the benefits of GLP-1 therapy, combining it with metformin has been shown to further improve both metabolic and reproductive outcomes

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Previous studies in obese rodents and diet-induced obesity models have shown that GEs primary site of action is central, particularly within hypothalamic regions such as the supramammillary nucleus, lateral hypothalamus, and the nucleus of the solitary tract (Tiano et al., 2015)