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We found that homozygous knockin of the L973F-IR in mice results in alterations in signaling similar to those observed in vitro, i.e., decreased IRS-1mediated signaling and increased Shc-mediated signaling, and these lead to impaired insulin sensitivity and modest increases in either tibial or whole-animal growth

Chronic inflammation produces thickening (lichenification) of the skin, especially in flexural regions