After careful analysis and comparison between the four treatment groups, we found that normal CSMCs are capable of producing several cytokines and chemokines at the basal level, while inducing inflammation by LPS stimulation caused a marked increase in the expression of TNF-, IL-1, M-CSF, TCA-3, and SDF-1
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Recombinant HGF was treated only with LASSS (at the same 1:8000 molar ratio to HGF as described earlier, without exposure to peroxynitrire) and then applied to centrifugal ultra-filtration (10-kDa MWCO) to thoroughly wash out un-reacted, free LASSS (FW: 238.39) prior to the c-met binding assay
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The high biocompatibility and tunable physicochemical properties of biopolymers such as hyaluronic acid (HA) render them suitable candidates as a MN material [16,17]