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Gut microbiome changes due to the use of antibiotics have been recently hypothesized in ME/CFS development, as antibiotics are known to alter the bacterial composition in the gut for up to four years, and in some cases, the changes may never fully recover [108]

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Certain small polyphenolic molecules, including resveratrol, fisetin, quercetin, and curcumin, have been found to modulate SIRT1 activity [131]

Erythrocyte peroxidases To cope with oxidative injuries, the erythrocytes have several enzymes that neutralize ROS or transform them into less reactive species