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Think of it like loosening a clamp on a pipe flow increases, but the effect is specific to that vascular tissue type and hasnt been shown to generalize beyond it
PMID: 30903796
No clinically relevant findings were observed for laboratory parameters, vital signs or ECG
Where the research should go next Key open questions include how much endogenous GLP1 increase is needed for sustained weight change, whether combinations of diet, prebiotics, probiotics and nutraceuticals can match injectable outcomes, and the longterm safety of such combinations
Yes, gastrointestinal side effects of semaglutide such as nausea, vomiting, and diarrhea can lead to dehydration and volume depletion, which may cause compensatory increases in heart rate that patients perceive as palpitations