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Losing 5 to 10% of body weight in addition to improved blood pressure or cholesterol is considered clinically significant

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462 Inhibition of the NF-B signaling pathway leads to the decreased production of inflammatory mediators, including adhesion molecules and chemokines, which are crucial for the recruitment of immune cells to sites of inflammation

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And I think we're entering a chapter that will fundamentally change how we treat obesity and its metabolic complications

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