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The FDA-approved indication is HIV-associated lipodystrophy specifically, reducing visceral adipose tissue accumulation

8 Studies have indicated that visceral adipose tissue may lead to higher circulating levels of insulin growth factor through worsening insulin resistance, thereby increasing the risk of carcinogenesis

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Ochi K, Ikari K, Naomi A, Momohara S

J Biol Chem 279(44):4570845712 Nithya K, Angeline T, As P, Aj A (2019) Prevalence of Glutamate carboxypeptidase II C1561T, reduced folate carrier 1 A80G, and methionine synthase A2756G gene polymorphisms in patients with type 2 diabetes mellitus among South Indians

Synovial fibroblast-miR-214-3p-derived exosomes inhibit inflammation and degeneration of cartilage tissues of osteoarthritis rats