Theoretically, if homocysteine concentrations become extremely low, substrate availability for glutathione synthesis could also be reduced
Shibagaki, N
Depletion of Methylfolate Directly Another way the body breaks the peroxynitrite cycle is by directly scavenging peroxynitrite using methylfolate.34 This results in oxidized methylfolate, which cannot be used until it has been regenerated back to its original form by ascorbic acid (vitamin C).36 This is another pathway that reduces folate levels, contributing to low thymidine levels and potential DNA strand breaks
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Alternative pathways to G6PD-dependent NADPH production exist in most human cells but not in erythrocytes, and the lack of protein synthetic machinery deprives the erythrocyte of the opportunity to replace enzyme that has been lost
Vitamin B12 deficiency: Case report and review of literature