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Subsequent experiments have demonstrated that C-MYC has the ability to impede ferroptosis through direct targeting of NCOA4, resulting in the downregulation of NCOA4 expression

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Hepatocytes take up medications, environmental chemicals, steroid hormones, bilirubin and metabolic products from the blood

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The mechanisms responsible for the induction and regulation of the autophagy programme are poorly understood but appear to involve FOXO transcription factors as well, in particular FOXO3