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Methanolic leaf extracts of Hawaiian kava cultivars showed stronger binding inhibition to several CNS receptorsincluding GABA A , dopamine D2, opioid (, ), and histamine (H1, H2)than root extracts, suggesting that compounds beyond the main kavalactones may contribute to the pharmacological effects of kava leaves

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Membrane-bound RAGE can recognize a variety of ligands (Table 1), triggering various intracellular cascades including NF-B, MAPK, and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), ultimately leading to the induction of inflammatory factors (Fig

Other trials also reported a reduction in body weight, HbA1c, and FPG in patients receiving combination therapy with SGLT-2i plus GLP-1RA [9, 23, 46]