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Contraindication(s) Since oral administration of acetylcysteine may result in vomiting or aggravate vomiting associated with acetaminophen overdosage, patients at risk of gastric hemorrhage (e.g., those with esophageal varices or peptic ulcers) should be evaluated with regard to the relative risks of upper GI hemorrhage and acetaminophen-induced hepatotoxicity and treatment with acetylcysteine given accordingly

Model Systems and Biological Factors The type of model system being used whether its an in vitro setup or an animal model significantly impacts dosing

doi: 10.1007/s00204-004-0557-0

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