is tirzepatide a glp-1 or 2 has quirk built into the molecule: instead of acting on one target, it activates two receptors at once — GIP and GLP-1. That's why it's called a dual agonist. The Tirzepatide | TRAVA

By demonstrating protective effects in a ciliopathy model, this study suggests that GLP-1 RAs may confer benefits beyond appetite suppression in patients with genetic obesity syndromes affecting ciliary function, further broadening the mechanistic rationale for targeting this pathway across diverse genetic etiologies of obesity

Yes, weight loss can help improve insulin sensitivity and reduce inflammationbut its not the whole picture

2.4.3 Local ovarian and endometrial microenvironments: inflammation, lipid metabolism, and receptivity In animal models of PCOS, attenuating local ovarian inflammation and oxidative stress, improving follicular structure and increasing ovulation counts (83, 92)

Of clinical significance, the incretin effect has been shown to be impaired in patients with T2DM, as GLP-1 secretion is deficient in these patients

Effect of intra-articular platelet-rich plasma vs placebo injection on pain and medial tibial cartilage volume in patients with knee osteoarthritis: The RESTORE Randomized Clinical Trial

If a person has too little GLP-1, this may lead to a person eating more during meals or snacking between meals