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In patients with AITD, autoreactive lymphocytes infiltrate the thyroid parenchyma, where they recognize thyroid antigens: Tg, TPO, TSH-R, and the sodium iodide symporter ( + lymphocytes and cytotoxic CD8 + lymphocytes ( In the pathogenesis of AITD, cells of both adaptive (specific) immunity - CD4 + -, CD8 + -lymphocytes, peripheral regulatory T-cells (pTreg), etc

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doi:10.1161/JAHA.114.001464

Polymorphic alleles of HRES-1/Rab4 have been associated with autoantibody production and predisposition to autoimmune diseases, such as SLE 31,32 and multiple sclerosis (MS) 33,34