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Bone erosion is a central feature of RA and is associated with disease severity

22,23 In patients with a normal or low-normal serum vitamin B 12 level, complete blood count results demonstrating macrocytosis, or suspected clinical manifestations, a serum methylmalonic acid level is an appropriate next step 1,2,6,18 and is a more direct measure of vitamin B 12 's physiologic activity

No serious adverse events were reported in healthy adults

Inflammatory bowel disease (IBD), marked by persistent and recurring gastrointestinal inflammation, is a significant global health issue

This is a formulation chemistry difference, not a sequence difference

Subsequently, cells were incubated with JC-1 dye for 2 hours