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It slows stomach emptying which leads to a slower flow of sugar from the bloodstream to your stomach, ultimately reducing the risk of a blood sugar spike

Endogenous GLP-1 has short-lived effects, but pharmaceutical GLP-1 RAs are engineered to have far longer half-lives and therefore sustained physiological impact

GIP receptor agonists work by targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) , stimulating additional insulin release while also influencing fat metabolism

Why Titration Matters A slow, stepwise escalation remains the key to safety

Since GLP-1RAs simultaneously target IR, lipid profiles, and hepatic fat, they provide an actionable pharmacological tool for risk-forward preventive strategies (78, 83)

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