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Three of the trials included both placebo and active control groups, while others were either placebo- or active-controlled

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Moreover, real-world evidence derived from the US Collaborative Network of TriNetX, which analyzed data from individuals with T2DM aged 18 years who initiated tirzepatide or a GLP-1 RA between June 1, 2022, and June 30, 2023, suggests that tirzepatide reduces the risk of all-cause mortality by 42%, MACE by 20%, and major adverse kidney events by 46% [84]

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Abbreviations HF: Heart failure T2DM: Type 2 diabetes mellitus SGLT2is: Sodium-glucose cotransporter-2 inhibitors GLP-1RAs: Glucagon-like peptide-1 receptor agonists HR: Hazard ratio References Abdul Basith Khan M, Hashim MJ, King JK, Govender RD, Mustafa H, Al Kaabi J

This is where exogenous antioxidantsobtained from dietary sources or supplementsbecome vital [24]