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GLP-1 metabolite GLP-1(936) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
Understanding these properties helps explain why 4 weeks works as the standard escalation interval
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However, a slight numerical increase in suicidal ideation was observed among liraglutide recipients, with nine cases (0.3%) in the liraglutide group compared to two cases (0.1%) in the placebo group [71]
Research points to GLP-1 as having a role in entraining the circadian rhythm of insulin release in the pancreas
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