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1 For the narrower MACE-3 composite of cardiovascular death, heart attack or stroke, there were 27 events in the Retatrutide arm and 23 in the placebo arm, for a hazard ratio of 1.12 (95% CI: 0.64 to 1.96)

On the other hand, the decrease in Trap5b breaks the balance of osteoclast fusion, and instead, there is an increased osteoclast fusion, which in turn enhances the risk of osteoporosis in women with PCOS