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Additionally, neurotoxins induce nuclear fragmentation, endoplasmic reticulum (ER) stress and unfolded protein response in catecholaminergic cells, which are associated with changes in proteasomal and chaperone activities, similar to those observed in PD [45,55]

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Oral and topical formulations are generally considered safer, while intravenous administration carries potential risks

We look forward to evaluating the efficacy of these multikinase inhibitors in clinical trials