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As mental health is now the most common reason people are on sick leave, or absent from work due to ill health, this has major implications for public health. Dr

As patients progress through dose escalationadvancing by 0.25mg or 0.5mg increments every 4 weeksthe pen's duration per patient shortens

In Phase 3 studies, retatrutide has been given as a once-weekly injection, usually starting at 2mg once weekly before increasing gradually every four weeks

In the 2023 New England Journal of Medicine trial, the retatrutide treatment groups showed not only gastrointestinal abnormalities but also a dose-dependent increase in heart rate

Additionally, certain medications, such as some steroids and antidepressants, may reduce effectiveness

NICE guidance recommends specialist weight management services and typically supports treatment with Wegovy for up to 2 years within the NHS