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Given the heterogenic nature of NAFLD, targeting metabolic, anti-inflammatory, or anti-fibrotic disease pathways simultaneously may exert an additive or synergistic effect and combination therapy may prove to be a an important tool in the future development of pharmacological treatment options

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A 2026 analysis of 194 studies found oral and topical glutathione helped with pigmentation, brightness, and hydration, while injected forms worked fast but faded fast and carried more risk

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