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Zou and others showed that glucosinolate and xanthotoxin present in Brassica juncea stimulated the expression of GSTE1 in the midgut of Spodoptera littoralis larvae after feeding

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Mol Psychiatry 28 , 564578 (2023)

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Subeffective dosages of metformin combined with L-NAME and 7-NI reduced CQ-induced scratching behavior, whereas L-arginine reversed the effect, indicating the involvement of the NO pathway in pruritus [14, 15]