Disruptions in the NVU, leading to BBB dysfunction and reduced CBF, are early events in various neurodegenerative diseases, including AD, PD, and ALS [85]
L-carnitine also helps move certain metabolic byproducts out of mitochondria, which supports normal cellular energy balance
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mitofusins (MFN1 and MFN2), which mediate outer-membrane fusion
Anecdotal reports suggest tolerance over extended periods, but unknown risks remain
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