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Tuesdays approval is backed by data from a Phase III trial comprising around 400 patients with a history of bipolar I disorder who are currently suffering from a manic episode

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As demonstrated for the DOR (see below), agonist-induced MOR phosphorylation is carried out hierarchically with first of all the S375, considered as the major phosphorylation site, followed by T370 (El Kouhen et al., 2001)

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But GLP-1s are far from perfect

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