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In addition, upon high-dose VitC administration, not only CD8+ T cells, but also macrophages showed increased tumour infiltration, and both enhanced Granzyme B production by cytotoxic T cells and enhanced interleukin 12 production by antigen-presenting cells were observed

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GH stimulation testing and random GH measurements have limited diagnostic utility for monitoring IGF-1 analogue use because exogenous LR3 suppresses pituitary GH output, creating a dissociation between GH and IGF-1 levels that may mislead interpretation [18]

In some embodiments, the otic formulation or composition comprises between about 1% to about 3% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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