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Loss of FSP1 does not affect System Xc- or glutathione synthesis but, even in the presence of functional GPX4, results in elevated phospholipid oxidation ( 2.1.3.4 Other molecular mechanisms In addition to GPX4, several regulatory pathways, including the PERK-NRF2-HO-1, AMPK/GSK-3/NRF2, and HSF1-HSPB1 axes, play critical roles in modulating ferroptosis independently of the GPX4 system

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