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Among these factors, c-Myc exhibited the most significant differential expression, and subsequent experimental validation further confirmed that c-Myc was markedly downregulated under Gln deprivation (Fig

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Perhaps most convincingly, rat studies in which plasma glucose and lactate levels were measured in the inferior vena cava, hepatic vein, hepatic portal vein and the aorta demonstrated that the plasma lactate concentration peaks in the hepatic portal vein, with a corresponding drop in the plasma glucose concentration