Isolation and Structure Determination of a Candidate Tetradepsipeptide Ethyl Ester ( m/z 453) and Octadepsipeptide Ethyl Ester ( m/z 837), Respectively The combined EtOH extracts obtained from cultures (100 mL) of strain F4810/72 were concentrated to about 25 mL in vacuum and, after dilution with H 2 O (1/10, v/v), aliquots (5 mL) were separated by means of preparative RP-HPLC on a PrepStar system (Varian, Darmstadt, Germany) consisting of two HPLC-pumps (Model SD-1), a two-wavelength UV detector (Prostar 325), a fraction collector (Model 701) and equipped with a 250 21.2 mm, 4 m, 90A, Jupiter Proteo column (Phenomenex) as the stationary phase
Immunogen: Ala2~Phe222
JAM-A, junctional adhesion molecule-A
Zomer et al., 2020
Vesicular stomatitis virus (VSV) first induces the antiviral activity of endogenously-produced interferon and then the generation of neutralizing antibodies to the VSV-G glycoprotein, measures that are critical for the control of this virus 95,96
Initial Treatment: For severe cases, doses can be 1000 mcg to 2000 mcg
